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Gastro-oesophageal reflux disease (GORD) is one of the most common disorders of the gastrointestinal tract1—with a prevalence of up to 26% of patients in Europe.2

What is GORD?

Gastro-oesophageal reflux disease is a common condition caused by hydrochloric acid and pepsin from the stomach leaking back up into the oesophagus. Symptoms that are associated with GORD include:2

  • heartburn
  • regurgitation 

Patients may also have:3

  • a cough or hiccups that keep coming back
  • a hoarse voice
  • bad breath
  • bloating and feeling sick

The following factors may cause or worsen the symptoms of GORD:3

factors associated with gord

  • irritant or acidic food or drinks, e.g. coffee, alcohol, citrus, spicy foods
  • being overweight
  • smoking
  • pregnancy
  • stress and anxiety
  • drugs such as aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs)
  • hiatus hernia

Managing the symptoms of GORD in adults—NICE clinical guideline 184

A concise summary of the NICE guidance on the investigation and management of dyspepsia and GORD including H. pylori testing and eradication, and endoscopy referral has been developed by Guidelines for Nurses.4

Managing symptoms of GORD

Management options for GORD symptoms include:

  • lifestyle advice:
    • healthy eating
    • weight reduction
    • smoking cessation
  • avoidance of known precipitants
  • use of medication (prescribed or over the counter)
    • proton pump inhibitors e.g. lansoprazole, omeprazole
    • H2 receptor antagonists e.g. cimetidine, ranitidine
    • antacids e.g. calcium carbonate, alumunium hydroxide
    • alginates
    • medical devices to maintain the integrity of the oesophageal mucosa e.g. Ziverel®

Information for patients on Treating the symptoms of Gastro-oesophageal Reflux Disease (GORD) can be downloaded and printed from this Norgine sponsored resource hub—this contains information on Ziverel®.

ZIVEREL, NORGINE and the sail logo are registered trademarks of the Norgine group of companies.


  1. Bredenoord A, Pandolfino J, Smout A. Gastro-oesophageal reflux disease. Lancet 2013; 381: 1933–1942.
  2. Sandhu D and Fass R. Current trends in the management of gastroesophageal reflux disease. Gut and Liver 2017; published online April 24: 1–10.
  3. NHS Choices. Heartburn and gastro-oesophageal reflux disease (GORD). Available at:
  4. Guidelines for Nurses. NICE GORD guideline. 


Date of preparation: June 2018