Pancreatic exocrine insufficiency guideline

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This management algorithm was developed by a multidisciplinary expert panel: Hambling C et al with the support of a grant from Mylan Ltd.

Pancreatic exocrine insufficiency (PEI) is the deficiency in (or absence of) amylase, protease, and lipase. The lack of these enzymes can prevent the normal breakdown and digestion of food, which can result in nutrient malabsorption and, therefore, malnutrition. Symptoms and signs of PEI include chronic diarrhoea, steatorrhoea, fatigue, and weight loss and in the long-term, PEI can affect cardiovascular disease and mortality.

This concise and useful management algorithm, exclusive to Guidelines, highlights how to assess a patient in primary care, when to refer, and therapeutic options for PEI.

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